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This combination of altered movement and increased fluid content creates conditions favorable to diarrhea, particularly in the first 48 weeks of treatment

Adults usually take one capsule per day with a meal that contains some healthy fat, or as directed by a healthcare professional

Therefore, although some studies claimed improvement of drug delivery to the brain via developed prodrugs based on the higher rate of BBB permeation of prodrugs compared to parent drugs, in fact, the rate of BBB permeation cannot be used for prediction of brain delivery efficacy